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Research Project:
Microbial Competitive Exclusion to Reduce Epizootic Pathogenic Bacteria in Swine and Cattle
Location:
Food and Feed Safety Research
Project Number: 6202-32000-018-00
Project Type:
Appropriated
Start Date: Nov 07, 2001
End Date: May 31, 2006
Objective:
The purpose of the proposed research is to develop and implement gastrointestinal management strategies that will reduce foodborne pathogen colonization of food producing animals. Specific objectives are to: 1) continue development of a defined competitive exclusion product capable of reducing human food pathogen colonization of swine; 2) in cooperation with CRADA partner, perform FDA pivotal field trials with the CE product to demonstrate efficacy of product and facilitate industry use in commercial
Approach:
State of the art continuous flow culture models will be used to test potential mitigation strategies with pure and mixed microbial populations and information gained from these studies will be validated via in vivo experimentation using animal models. Strategies to be tested include: 1) competitive exclusion, 2) chlorate supplementation, 3) inhibition of pathogen attachment and 4) artificial manipulation of regulatory activities. Knowledge gained will be used to develop and implement practical and efficacious mitigation strategies to rid the pathogens from food producing animals prior to slaughter.
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