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Appendix A: project focus areas

Research Type

Secondary Focus Area

Tertiary Focus Area

Project Number

Project Title

Brain & Nervous System

Mechanistic

   

DoD-92

Traumatic Experiences Persistently Enhance Cue-dependent Learning: Toward an Animal Model of Chronic Stress and Posttraumatic Stress Disorder

Epidemiology Research

Symptoms/General Health

 

DoD-23

Acute and Long-Term Impact of Deployment to Southwest Asia on the Physical and Mental Health of Soldiers and their Families

Epidemiology Research

Symptoms/General Health

 

DoD-52

Female Gender and Other Potential Predictors of Functional Health Status Among Persian Gulf War Veterans

Epidemiology Research

   

DoD-82

Feasibility of Developing a Registry of PTSD Affected Veteran Sib Pairs

Clinical Research

Prevention

 

DoD-83

Risk for Stress-related Substance Abuse: the Effects of Family History of Alcoholism

Clinical Research

Symptoms/General Health

 

DoD-84

Psychobiologic Alterations in Persian Gulf War Veterans with and without PTSD

Clinical Research

Treatment

Symptoms/

General Health

DoD-85

CNS Cytokines and CRH in Gulf War Veterans with Multiple Unexplained Symptoms

Clinical Research

   

DoD-86

Effects of Combat Stress on Structure and Function of the Hippocampus

Epidemiology Research

Prevention

 

DoD-87

Measurement and Validation of Psychosocial Risk and Resilience Factors Accounting for Physical and Mental Health and Health-Related Quality of Life among PGWVs

Clinical Research

Symptoms/General Health

 

DoD-89

Limbic Blood Flow and Opiate Receptor PET in Posttraumatic Stress Disorder

Clinical Research

   

VA-20

Psychological Adjustment in Operation Desert Shield/Storm Veterans

Mechanistic

   

DoD-91

Neurological and Circadian Substrates of PTSD-like Behaviors

Mechanistic

   

DoD-80

Molecular Regulation of corticosteroid Receptor Expression in stress-Responsive Cells

Clinical Research

Symptoms/General Health

 

VA-54

Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress

Clinical Research

   

VA-12

Psychological Assessment of Operation Desert Storm Returnees

Clinical Research

Symptoms/General Health

 

VA-7

Desert Storm Reunion Survey

Clinical Research

Symptoms/General Health

 

VA-4A

Evaluation of Cognitive Functioning of Persian Gulf Veterans

Clinical Research

Symptoms/General Health

 

VA-4B

Evaluation of Neurological Functioning in Persian Gulf Veterans

Clinical Research

Symptoms/General Health

 

VA-10

Memory and Attention in PTSD

Clinical Research

Symptoms/General Health

 

VA-6A

Psychosocial, Neuropsychological and Neurobehavioral Assessment (Project I)

Clinical Research

Diagnosis

 

VA-4F

Validity of Computerized Tests

Clinical Research

   

VA-21

A Comparison of PTSD Symptomatology among Three Army Medical Units Involved in ODS

Clinical Research

   

VA-13

Neurobehavioral Aspects of Persian Gulf Experiences: A Pilot Study

Clinical Research

Treatment

 

DoD-90

SPECT Benzodiazepine Receptor and MR Imaging in PTSD

Clinical Research

   

VA-50

Neuropsychological findings in a sample of Operation Desert Storm veterans

Epidemiology Research

   

VA-36

Stress Symptoms and Their Causal Attribution in Desert Storm Veterans

Clinical Research

Chemical Weapons

 

DoD-63

PGW Veterans: Epidemiological and Clinical Evidence for Residual Organophosphate Neurotoxicity

Clinical Research

Symptoms/General Health

 

DoD-41

Evaluation of Muscle Function in Persian Gulf Veterans

Clinical Research

Symptoms/General Health

 

DoD-40

Psychological and Neurobiological Consequences of the Gulf War Experience

Clinical Research

Symptoms/General Health

 

DoD-36

Fatigue in Persian Gulf Syndrome-Physiologic Mechanisms

Clinical Research

Symptoms/General Health

Diagnosis

DoD-67

Antibacterial Treatment method based upon the excretion of dead and decaying spherical bacteria

Clinical Research

Symptoms/General Health

 

VA-51

Psychobiological Assessment of Desert Storm Veterans

Clinical Research

Diagnosis

 

DoD-32

Neuropsychological Functioning in Persian Gulf Era Veterans

Clinical Research

Symptoms/General Health

Diagnosis

DoD-31

Dysregulation of the Stress Response in the Persian Gulf Syndrome

Clinical Research

Symptoms/General Health

 

VA-11

Neuropsychological Functioning in Veterans

Clinical Research

Symptoms/General Health

 

VA-9

Evaluation of Cognitive Functioning in Persian Gulf War Veterans Reporting War-related Health Problems

Mechanistic

Treatment

 

DoD-6A

Combat Stress Pharmacotherapy

Clinical Research

Diagnosis

Prevention

DoD-6B

Combat Stress Diagnosis, PTSD Prevention

Clinical Research

Symptoms/General Health

 

HHS-5

Cognitive Function and Symptom Patterns in Persian Gulf Veterans

Chemical Weapons

Clinical Research

Diagnosis

 

VA-47

Retrospective Verification of Mustard Gas Exposure

Mechanistic

Prevention

 

DoD-51

Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses

Mechanistic

   

DoD-50

Toxicokinetics of 0-Ethyl S-(2-Diisopropylaminoethyl) Methylphosphonothioate [(+)-VX] in Rats, Hairless Guinea Pigs and Marmosets - Identification of Metabolic Pathways

Mechanistic

Brain & Nervous System

 

DoD-53

Long-Term Effects of Subclinical Exposures to Sarin

Mechanistic

Diagnosis

 

VA-6D

DNA Damage from Chemical Agents and Its Repair (Project IV)

Epidemiology Research

   

VA/DoD-2DA**

Follow-Up investigation of troops exposed to nerve agents at Aberdeen Proving Ground

Clinical Research

Pyridostigmine Bromide

Prevention

DoD-60

Butyrylcholinesterase Genetic Variants in Persons with Gulf War Illness

Development

Diagnosis

 

DoD-49

Diagnosis and Dosimetry of Exposure to Sulfur Mustard: Development of Standard Operating Procedures and Exploratory Research on Protein Adducts

Epidemiology Research

Symptoms/General Health

 

DoD-69

Five Year Follow-Up of arm Personnel Exposed to Chemical Warfare Agents

Depleted Uranium

Mechanistic

Environmental Toxicology

 

DoD-7B

Carcinogenicity of Depleted Uranium Fragments

Mechanistic

Environmental Toxicology

 

DoD-7A

Health Risk Assessment of Embedded Depleted Uranium: Behavior, Physiology, Histology, and Biokinetic Modeling

Diagnosis

Clinical Research

   

DoD-47

Study of Mycoplasmal Infections in Gulf War Veterans

Clinical Research

Symptoms/General Health

 

HHS-6

Defining Gulf War Illness

Development

   

DoD-66

Testing for mycoplasmal infection replicability of nucleoprotein gene tracking and forensic polymerase chain reaction

Development

   

DoD-12

Forward Deployable Diagnostics for Infectious Diseases

Environmental Toxicology

Mechanistic

Prevention

 

VA-4E

The Aromatic Hydrocarbon Receptor (AhR) as a Biomarker of Susceptibility

Clinical Research

Symptoms/General Health

 

VA-4D

Evaluation of Respiratory Dysfunction Among Gulf War Veterans

Clinical Research

Brain & Nervous System

Interactions

VA-48

Cross-Sensitization as a CNS Model for Gulf War Chemical Intolerance

Epidemiology Research

   

VA-4C

Gulf War And Vietnam Veterans Cancer Incidence Surveillance

Development

   

DoD-16

Kuwait Oil Fire Health Risk Assessment

Development

Interactions

 

DoD-34

Characterization of Emissions from Heaters Burning Leaded Diesel Fuel in Unvented Tents

Development

   

DoD-19

Persian Gulf Veterans Health Tracking System

Development

   

DoD-18

Kuwait Oil Fires Troop Exposure Assessment Model (TEAM)

Epidemiology Research

   

DoD-13

Effects of Persian Gulf War Service on Military Working Dogs

Mechanistic

Brain & Nervous System

Chemical Weapons

DoD-22

Chronic Organophosphorous Exposure and Cognition

Mechanistic

Prevention

 

HHS-3

Biomarkers of Susceptibility and Polycyclic Aromatic Hydrocarbon (PAH) Exposure in Urine and blood Cell DNA from U.S. Army Soldiers Exposed to Kuwaiti Oil Well Fires

Immune Function

Mechanistic

Interactions

Environmental Toxicology

HHS-7

Immunotoxicity of Dermal Permethrinand Cis-Urocanic Acid

Clinical Research

Brain & Nervous System

 

DoD-88

Clinical Relevance of novel Immunological Markers in PTSD

Clinical Research

Symptoms/General Health

 

VA-17

Immunological Evaluation of Persian Gulf Veterans

Clinical Research

Symptoms/General Health

 

VA-6B

Clinical and Neuroendocrine Aspects of Fibromyalgia (Project II)

Clinical Research

   

DoD-48

Assessment of Genomic Instability via Chromosome 7 Inversion Frequency in a Gulf-War Syndrome Cohort vs Selected Control Groups

Clinical Research

Symptoms/General Health

Environmental Toxicology

VA-5C

Effects of Exertion and Chemical Stress on Persian Gulf Veterans

Clinical Research

Brain & Nervous System

 

VA-5B

Physiological and Psychological Assessments of Persian Gulf Veterans

Interactions

Mechanistic

Pyridostigmine Bromide

Brain & Nervous System

DoD-75

Toxic Interactions of Prophylactic Drugs and Pesticides

Mechanistic

Chemical Weapons

Brain & Nervous System

DoD-72

Long-term Effects of Subchronic Exposure to Sarin, Alone and with Stress or Other Chemicals

Mechanistic

Immune Function

Pyridostigmine Bromide

DoD-81

Immunotoxicity due to Coexposure to DEET, Pyridostigmine, and Stress

Mechanistic

Chemical Weapons

Brain & Nervous System

DoD-78

Experimental Models of Gulf War Syndrome

Mechanistic

Pyridostigmine Bromide

Brain & Nervous System

DoD-2

Physiological and Neurobehavioral Effects in Rodents from Exposure to Pyridostigmine, Fuels, and DEET

Mechanistic

Pyridostigmine Bromide

Immune Function

DoD-76

Evaluations of Immunotoxicity due to Concurrent Exposure to DEET, Pyridostigmine, and JP-8 Jet Fuel

Mechanistic

Chemical Weapons

Pyridostigmine Bromide

DoD-62

Sarin and Pyridostigmine Interaction under Physical Stress: Neurotoxic Effects in Mice

Development

Environmental Toxicology

 

HHS-8

Strategy to Identify Non-Additive Response to Chemical Mixtures

Mechanistic

Pyridostigmine Bromide

Brain & Nervous System

DoD-37

Neurobehavioral and Immunological Toxicity of Pyridostigmine, Permethrin, and DEET in Male and Female Rats

Mechanistic

Pyridostigmine Bromide

 

DoD-77

Percutaneous Absorption of Chemical Mixtures Relevant to the Gulf War

Mechanistic

Chemical Weapons

Pyridostigmine Bromide

DoD-61

Neurophysiologic and Neuropathologic Effects in Monkeys of Low Level Exposures to Sarin, Pyridostigmine, Pesticides, and Botulinum Toxoid

Mechanistic

Chemical Weapons

Pyridostigmine Bromide

DoD-56

Low-Level Sarin Neurotoxicity and Its Modulation by Pyridostigmine

Mechanistic

Brain & Nervous System

Chemical Weapons

DoD-54

Assessment of Subchronic Neurobehavioral and Neuropathologic Effects in Rats

Mechanistic

Chemical Weapons

Pyridostigmine Bromide

DoD-55

Low-Level Exposure to GB Vapor in Air: Diagnosis/Dosimetry, Lowest Observable Effect Levels, Performance-Incapacitation, and Possible Delayed Effects

Leishmaniasis

Mechanistic

Prevention

 

VA-15

Vaccine-Mediated Immunity Against Leishmaniasis

Development

Diagnosis

 

DoD-8B

Development of a Leishmania Skin Test Antigen (LSTA)

Clinical Research

Diagnosis

Treatment

VA-6E

Clinical and Epidemiology Leishmania Research

Mechanistic

Treatment

 

DoD-9

Identification of the Genetic Factors Which Control Tropism in Leishmania

Mechanistic

Prevention

 

VA-16

Protective Immunity in Experimental Visceral Leishmaniasis

Development

Diagnosis

 

DoD-38

Diagnostic Antigens of Leishmania tropica

Development

Diagnosis

 

DoD-8A

Serologic Diagnosis of Viscerotropic Leishmaniasis (VTL)

Mortality

Epidemiology Research

   

VA-1

Mortality Follow-up Study of Persian Gulf Veterans, First Update

Epidemiology Research

   

DoD-15

Comparative Mortality Among US Military Personnel Worldwide During Operations Desert Shield and Desert Storm

Pyridostigmine Bromide

Mechanistic

Environmental Toxicology

 

VA-6C

Neurotoxicity of Environmental Pollutants and Warfare Agents (Project III)

Epidemiology Research

   

DoD-17

Retrospective Studies Involving Military Use of Pyridostigmine as a Pretreatment for Nerve Agent Poisoning

Clinical Research

Brain & Nervous System

Prevention

DoD-64

Individual Differences in Neurobehavioral Effects of Pyridostigmine

Mechanistic

Prevention

 

DoD-33

Effects of Pyridostigmine in Flinders Line Rats Differing in Cholinergic Sensitivity

Mechanistic

Interactions

 

DoD-10

Pyridostigmine Synergistic Toxicity Study

Clinical Research

   

DoD-11

Male/Female Differential Tolerances to Pyridostigmine Bromide

Epidemiology Research

Prevention

 

DoD-21

Study of Variability In Pyridostigmine Inhibition of Blood Cholinesterases in Healthy Adults and Individuals With Symptoms Following Participation in Operation Desert Storm

Mechanistic

Brain & Nervous System

 

DoD-59

Pyridostigmine-induced Neurodegeneration: Role of neuronal Apoptosis

Mechanistic

Brain & Nervous System

 

DoD-79

Time Course of Stress-induced Impairment of Blood Brain Barrier

Mechanistic

Brain & Nervous System

 

VA-49

Sensitivity to Pyridostigmine Bromide: Persistent Neural Dysfunction

Mechanistic

Interactions

 

VA-5D

Effects of Genetics and Stress on Responses to Environmental Toxins

Reproductive Health

Epidemiology Research

   

HHS-4

Suspected Increase of Birth Defects and health Problems Among Children Born to Persian Gulf War Veterans in Mississippi

Epidemiology Research

   

DoD-1C

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 3: A comparative study of pregnancy outcomes among Gulf War veterans and other active-duty personnel

Epidemiology Research

   

DoD-1G

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 7: Prevalence of Congenital Anomalies Among Children of Persian Gulf War Veterans

Epidemiology Research

   

DoD-1D

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 4: Adverse Reproductive Outcomes in Gulf War Veterans

Epidemiology Research

   

DoD-35

Feasibility of Investigating Whether There is a Relationship Between Birth Defects and Service in the Gulf War.

Clinical Research

Symptoms/General Health

Immunology

DoD-44

Investigation of Seminal Plasma Hypersensitivity Reactions

Symptoms/General Health

Epidemiology Research

Diagnosis

 

HHS-2

Disease Cluster in a Pennsylvania Air National Guard Unit, EPI-AID 95-18

Epidemiology Research

Reproductive Health

 

DoD-30

Epidemiological Studies Persian Gulf War Illnesses, PG Women's Health Linkage Study

Epidemiology Research

   

DoD-46

Exploratory Data Analysis with the CCEP Database

Clinical Research

Brain & Nervous System

 

DoD-58

Illness Among Persian Gulf War Veterans: Case Validation Studies

Clinical Research

Brain & Nervous System

 

DoD-57

Physiologic Effects of Stress in Gulf War Veterans

Clinical Research

Immunology

Brain & Nervous System

DoD-42

The Symptomatic Persian Gulf Veterans Protocol: An Analysis of Risk Factors with an Immunologic and Neuropsychiatric Assessment

Clinical Research

Brain & Nervous System

Reproductive Health

DoD-45

Physical and Emotional Health of Gulf War Veterans Women

Clinical Research

Brain & Nervous System

 

VA-4Core

Boston Environmental Hazards Research Center Program

Clinical Research

   

VA-40

Musculoskeletal Symptoms in Gulf War Syndrome

Epidemiology Research

   

VA-46

Diarrhea in Persian Gulf Veterans: An Irritable Bowel-Like Disorder

Epidemiology Research

   

DoD-39

A Controlled Epidemiological and Clinical Study into the Effect of Gulf War Service on Servicemen and Women of the United Kingdom Armed Forces

Epidemiology Research

   

DoD-74

Relationship of Stress Exposures to Health in Gulf War Veterans

Clinical Research

Brain & Nervous System

 

VA-8

Psychological Test Data of Gulf War Veterans Over Time

Epidemiology Research

   

VA-5A

Health and Exposure Survey of Persian Gulf Veterans

Epidemiology Research

   

VA-6Core

Core Program: Portland Environmental Hazards Research Center: Environment, Veterans Health and the Gulf War Syndrome.

Epidemiology Research

   

HHS-1

Health Assessment of Persian Gulf War Veterans from Iowa

Clinical Research

   

DoD-1A

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 1: A Study of Symptoms Among 1500 Seabees

Epidemiology Research

   

DoD-1B

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 2: A comparative study of hospitalizations among Active-duty personnel who participated in the Gulf War and similar personnel who did not.

Clinical Research

Brain & Nervous System

 

VA-5Core

East Orange Environmental Hazards Research Center Program

Epidemiology Research

   

DoD-1E

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 5: Seabee Health Study.

Epidemiology Research

   

DoD-1F

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study6: A Comparison of Nonfederal Hospitalization Experience Among Veterans in California who have separated from active service: PGW vs EV.

Epidemiology Research

   

DoD-14

Risk Factors Among US Army Soldiers for Enrolling on the Department of Veterans Affairs Gulf War Registry

Epidemiology Research

   

DoD-71

A Comparison of Post Deployment Hospitalization Between Vietnam and Gulf War Veterans

Epidemiology Research

   

DoD-4

The General Well-Being of Gulf War Era Service Personnel from the States of Pennsylvania and Hawaii: A Survey

Epidemiology Research

   

VA/DoD-2DB**

Patterns of Pre-Persian Gulf War Illness and Health Care Seeking, Pilot Study

Epidemiology Research

   

VA-2

National Health Survey of Persian Gulf Veterans

Epidemiology Research

   

DoD-73

Post-deployment Morbid Stress, Behavior and Health: Developing a Model for Predicting Morbidity, Mortality, and other Adverse Outcomes

Clinical Research

   

VA-18

Chronic Gastrointestinal Illness in Persian Gulf Veterans

Epidemiology Research

   

DoD-70

War Syndromes from 1900 to the Present: Symptom Patterns and Long-term Health Outcomes

Epidemiology Research

   

VA-2A

VA National Survey of Persian Gulf Veterans - Phase I

Epidemiology Research

   

VA-2B

VA National Survey of Persian Gulf Veterans - Phase II

Epidemiology Research

Brain & Nervous System

Diagnosis

VA-2C

VA National Survey of Persian Gulf Veterans - Phase III

Epidemiology Research

   

VA-3

Use of Roster of Veterans Who Served in Persian Gulf Area

Epidemiology Research

   

VA/DoD-2VB**

Patterns of Pre-Persian Gulf War Illness and Health Care Seeking, Pilot Study

Epidemiology Research

   

DoD-20

A Statistical Study Correlating the Reported Cases of Gulf War Syndrome to Battlefield Locations of Afflicted US Army Personnel During the Iraq-Kuwait War; Part 1: Method to Related Troop Deployment and the Reported Cases of Gulf War Syndrome and Probable Incidence of Maladies Defined by ICD-9-CM

Treatment

Clinical Research

General Health

 

VA-55

Antibiotic Treatment of Gulf War Veterans' Illnesses

Clinical Research

   

DoD-65

Multi-disciplinary Pathophysiologic studies of neurotoxic Gulf War related syndromes leading to diagnosis and treatment

Clinical Research

Symptoms/General Health

 

VA/DoD-1D**

A Randomized, Multi-Center, Controlled Trial of Multi-Modal Therapy in Veterans with Gulf War Illnesses

Clinical Research

Symptoms/General Health

 

VA/DoD-1V**

A Randomized, Multi-Center, Controlled Trial of Multi-Modal Therapy in Veterans with Gulf War Illnesses