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Search IRISThe Search IRIS page enables users to find IRIS files, identify substances with similar toxicological properties, and conduct other comparative analyses of IRIS data. The CASRN and Keyword Search options enable users to determine whether a substance not included on the List of IRIS Substances is listed under a synonym or addressed in IRIS as part of a broader substance category (e.g., Lead and compounds, PCBs). The Keyword Search can also be used to locate information on general topics either within the IRIS summaries and Toxicological Reviews themselves or throughout the entire IRIS Website, including IRIS guidance documents and other background information.
The Search IRIS page also enables users to find substances with similar toxicological properties. The Critical Effect/Precursor Effect/Tumor Type Search enables the user to find substances that effect similar organs or tissues in similar ways. The Evidence for Human Carcinogenicity Search enables the user to find substances by the weight-of-evidence characterizations used in the 1986, 1996, and 1999 Carcinogen Risk Assessment Guidelines. The Quantitative Toxicity and Related Values Search enables users to identify substances within ranges of cancer and noncancer dose-response values, including RfDs, RfCs, slope factors, and unit risks. The Uncertainty and Modifying Factors Search enables users to analyze sources of uncertainty and variability and the application of uncertainty factors for derivation of RfDs and RfCs across the IRIS database.
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