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Acephate (CASRN 30560-19-1)
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development. Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the Full IRIS Summary to put this information into complete context. For definitions of terms in the IRIS Web site, refer to the IRIS Glossary. Status of Data for AcephateFile First On-Line: 09/07/1988 Last Significant Revision: 05/01/1989
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| Critical Effect | Experimental Dose | |||
|---|---|---|---|---|
| Inhibition of brain ChE | LEL : 0.12 mg/kg-day | 30 |
1 |
4 x10-3 mg/kg-day |
The Experimental Dose listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.
Weight of Evidence Narrative:
The classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.
This may be a synopsis of the full weight-of-evidence narrative. See Full IRIS Summary.
| Oral Slope Factor(s) | Extrapolation Method |
|---|---|
| 8.7x10-3 per mg/kg-day | Linearized multistage procedure, extra risk |
Drinking Water Unit Risk(s):
2.5x10-4 per mg/L
| Risk Level | Concentration |
|---|---|
| E-4 (1 in 10,000) | 4x10-1 mg/L |
| E-5 (1 in 100,000) | 4x10-2 mg/L |
| E-6 (1 in 1,000,000) | 4x10-3 mg/L |
Dose-Response Data (Carcinogenicity, Oral Exposure)
Tumor Type: Liver adenomas and carcinomas
Test Species: Mouse/ CD-1, female
Route: Oral, Diet
Reference: Chevron Chemical, 1982a
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