Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices,
and the Office of Research and Development.
Weight of Evidence Characterization
Weight of Evidence (1986 US EPA Guidelines):
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans)
Weight of Evidence Narrative:
Limited evidence of the association between occupational creosote contact and subsequent tumor formation, sufficient evidence of local and distant tumor formation after dermal application to mice, and some evidence of mutagenic activity, as well as the well-documented carcinogenicity of other coal tar products to humans.
This may be a synopsis of the full weight-of-evidence narrative. See Full IRIS Summary.
