VRC
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Vaccine Research Center
Scientific Updates
West Nile Virus Vaccine Development
The NIAID Vaccine Research Center is currently conducting
pre-clinical testing of a West Nile virus vaccine. The VRC
proposes to use an existing codon modified gene-based DNA
plasmid vaccine platform to make DNA constructs that express
WN virus proteins. These vaccine constructs are currently
undergoing immunogenicity and viral challenge studies in rabbits.
The VRC in collaboration with Vical, Inc. has completed GMP
production of the vaccine for a Phase I trial scheduled for
early 2005.
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