Project Number: 1275-22000-192-06
Project Type: Specific C/A

Start Date: Jun 02, 2004
End Date: Sep 30, 2008

Objective:
UNDERSTAND THE STRUCTURAL/PHYSIOCHEMICAL BASIS OF THE ACTIVITY OF CHEMICALS AS MOSQUITO REPELLANTS, ATTRACTANTS, AND TOXICANTS. CARRY OUT COMPUTER-ASSISTED DESIGN OF NOVEL REPELLENT, ATTRACTANT, AND TOXICANT CHEMICALS BASED ON THE LIBRARY OF PROPERTY AND BIOLOGICAL TEST DATA PROVIDED BY THE COOPERATOR BASF, AS WELL AS ALREADY KNOWN AND EFFECTIVE CHEMICAL AGENTS. In support of Deployed War Fighters (DOD) Protection Initiative.

Approach:
WILL USE THE METHOD OF COMPUTER-ASSISTED DESIGN AND SCREENING OF CHEMICAL LIBRARIES BASED ON QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSARS), QUANTITATIVE MOLECULAR SIMILARITY ANALYSIS (QMSA), AND COMBINATORIAL CHEMISTRY.

Project Team

Klun, Jerome Chauhan, Kamal Subhash Basak - Senior Research Scientist 301-504-9388

Related National Programs

Veterinary, Medical and Urban Entomology (104)