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Display category headings
Research Project:
Developing Tools for the Differentiation of Endemic Viruses from High Consequence Pathogens: Rapid Nucleic Acid Based Tests for Pestivirus
Location:
Virus and Prion Diseases of Livestock
Project Number: 3625-32000-070-02
Project Type:
Specific C/A
Start Date: Sep 24, 2002
End Date: Aug 31, 2005
Objective:
The objective of this cooperative research project is to provide differentiation between eradicated/exotic viruses and endemic viruses that produce clinical manifestations similar to eradicated/exotic viruses.
Approach:
Presumptive diagnosis of viral infections in the field are often made based on classic" clinical signs. Clinical manifestation such as the formation of vesicles in and around the mouth observed with foot and mouth disease virus (FMDV) or hemorrhages and abortions observed with classical swine fever virus (CSFV) are not unique to these eradicated viruses and may be observed after infection with viruses that are presently endemic to the U.S. While tests are available that will identify eradicated/exotic viruses such as FMDV and CSFV, tests may not be readily available for viruses that may be confused with them based on clinical signs. Sequences of divergent pestiviruses will be compared to identify genomic motifs that are 1) specific for all pestiviruses or 2) specific for individual pestivirus species. Tests will be developed based on these motifs and validated using material from the pestivirus collections of the USDA and field samples.
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