Project Number: 3625-32000-063-02
Project Type: Reimbursable

Start Date: Dec 09, 2003
End Date: Sep 30, 2004

Objective:
Evaluate immune responses of reindeer sensitized to Mycobacterium bovis BCG; Evaluate immune responses and diagnostic tests in reindeer experimentally infected with pathogenic M. bovis; Evaluate lesions in reindeer experimentally infected with M. bovis; Evaluate immune responses and lesion development in white-tailed deer experimentally infected with M. bovis

Approach:
A group of reindeer will be sensitized with M. bovis BCG and matched with a group of non-sensitized control animals. Blood samples will be collected and skin tests will be conducted periodically throughout the study period. Various immune function assays will be conducted to monitor immune responses. In the second study, reindeer will be challenged with virulent M. bovis. Blood samples will be collected and skin tests will be conducted similare to the first study. In addition, tissue samples will be collected at various times to characterize the progression of disease in reindeer. White-tailed deer will be experimentally challenged with M. bovis using two routes of inoculation and three dosages. Immune responses will be monitored by evaluating blood collected at various times and conducting skin tests. Lesions will be characterized at the conclusion of the study. BSL 3 recertified through 10/15/04. (IBC 239)

Project Team

Palmer, Mitchell Whipple, Diana Waters, Wade

Related National Programs

Animal Health (103)