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Display category headings
Research Project:
Plant-Parasitic Nematode Control: Endogenous Development, Genetic and Biochemical Targets
Location:
Nematology Laboratory
Project Number: 1275-22000-196-00
Project Type:
Appropriated
Start Date: Nov 26, 2002
End Date: Oct 31, 2007
Objective:
1. Identify endogenous hormones, enzymes and their genes critical for reproduction and survival of plant-parasitic nematodes; 2) Characterize genes and proteins involved in arrested or normal reproductive development associated with nematode reaction to host plant and environmental factors; 3) Elucidate chemical structures, metabolism and physiological roles of nematode steroids and other bioactive lipids.
Approach:
1. Identify and characterize FMRFamide-like peptides and other regulatory neurohormones, and aminopeptidases and related proteases which control neuropeptide biosynthesis and activity; 2) Develop molecular biological methods to characterize HSP90, its gene, and their roles in the regulation of nematode-host interactions and parasite development; 3) Elucidate steroid and lipid metabolic pathways in nematodes, and determine the effects of inhibitors of these pathways on biochemical and developmental processes in plant-parasitic nematodes.
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