Project Number: 5438-32000-025-00
Project Type: Other OICD

Start Date: Aug 28, 2002
End Date: Nov 27, 2005

Objective:
The objective of this research project is provide a secure, well-annotated database of nucleotide sequence data, and associated biological data, of relevant viral pathogens affecting livestock.

Approach:
The core of this system will be a database containing a set of well-annotated genomic sequences of viral pathogens currently on the threat list, and sequences of known pathogens that produce disease similar to those caused by threat list agents. The core genomic sequences in the database, termed reference sequences, will be curated by experts to ensure that they are of the highest quality possible since they will provide the basis for both experimental and epidemiologic/forensic analyses. In addition, reference sequences will be highly annotated in terms of their source (host species, geographic origin, etc.), phenotypes (serotype, permissive cell lines, plaque size, etc.) and clinical data (disease signs, lesions caused, kinetics of infection, etc.). Beyond providing the basis for analysis of outbreak pathogen isolates, this high quality core of reference sequences will enable the discovery of associations between pathogen sequence and phenotypes on a scale not yet approached in livestock infectious disease research. Other sequence data will also be contained in the database. This data would include well-annotated partial sequences of pathogens, non-curated sequences and genomic sequences with limited annotation. Special Appropriation for Homeland Security ($1,500,000).

Project Team

Kappes, Steven Laegreid, William Keele, John

Project Annual Reports

FY 2003

Related National Programs

Food Animal Production (101)