HomeResearchExtramural Research Sequences, Maps and BAC Libraries Program

Sequences, Maps and Bacterial Artificial
Chromosome (BAC) Libraries Program

The Genome Sequencing Program

Sequences, Maps and BAC Libraries New  Genomic Sequencing Targets Requests for Development of New Genomic Resources Genome Sequencing Proposals BAC Library Proposals

	Overview
	Policy Development and Program Coordination
	Meeting Reports and Workshop Summaries
	Funding Opportunities
	Program Staff

Overview

The Genome Sequencing Program is responsible for the administration and support of research directed to the highly efficient construction of physical maps, large-scale sequencing and genomic resource production for entire genomes.

Policy Development and Program Coordination

Data Release and Intellectual Property

• NHGRI Rapid Data Release Policy:
  New, draft policy on rapid release of data from large-scale sequencing projects. (February 2003)



• BAC Resource Network
  A set of cooperative agreements form the National Institutes of Health (NIH) BAC Resource Network to increase the national BAC library-making capacity.



• Data Release and Access Principles and Policy (2000)



• Update of NHGRI Policy for Release and Database Deposition of Sequence Data (December 2000)
  • NHGRI Policy for Release and Database Deposition of Sequence Data (March 1997)



• NIH-DOE Guidelines for Access to Mapping and Sequencing Data and Material Resources
  (For additional information regarding data release for large-scale sequencing of model organism genomes, see: Guyer, M. Statement on the Rapid Release of Genomic DNA Sequence [genome.org]. Genome Research: May 1998; 8(5): 413.)



• NHGRI Policy Regarding Intellectual Property of Human Genomic Sequence
  Policy on Availability and Patenting of Human Genomic DNA Sequence Produced by NHGRI Pilot Projects. (April 1996)

Quality Control and Assessment

• BAC Library Quality Assessment Standards (January 2002)
• NHGRI Standard for Quality of Human Genomic Sequence
  Quality Assessment Exercises (Spring 1998)

Sequence Finishing Standards

• Standard Finishing Practices and Annotation of Problem Regions for the Human Genome Project

Human Subjects

• The Use of Human Subjects in Large-Scale DNA Sequencing
  (Updated August 1998)

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Meeting Reports and Workshop Summaries

April 14-15, 2004: Exploring Cancer through Genomic Sequence Comparisons
A workshop held jointly by the National Cancer Institute and the National Human Genome Research Institute to assess the value of a project to catalogue all of the DNA sequence changes that occur in tumorigenesis.

To view this pdf you will need Adobe Acrobat Reader.

July 9-10, 2001: Developing Guidelines for Choosing New Genomic Sequencing Targets
A workshop to discuss the opportunities available from comparative genome analysis using whole genome data sets, and develop a set of guidelines that investigators should address in their proposals.

July 25, 2000: Trace Repository Workshop
A workshop to establish an archive for sequence traces from new projects, such as the sequencing of the mouse genome, and an archive for data already generated and archived at the centers as part of the human sequencing project.

September 3-4, 1998: Large-Scale Sequencing Workshop
A strategy workshop for accelerated production of a 'rough draft' sequence of human DNA.

December 18-19, 1997: Human DNA Sequencing Planning Workshop
A workshop to discuss the critical issues in large-scale sequencing that should be taken into account in formulating the next NHGRI five-year plan.

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Funding Opportunities

RFA HG-03-002 [grants1.nih.gov]: Large-Scale Sequencing Capacity

• Supplemental Information for RFA HG-03-002: Large-Scale Sequencing Capacity Formats
  Formats available online that are required for reporting production statistics and costs, and proposed costs for sequence production.

PAR-02-021: Centers of Excellence in Genomic Science (CEGS)
The CEGS program supports multi-investigator, interdisciplinary teams to develop innovative genomic approaches to address a particular biological problem. A CEGS project will address a critical issue in genomic science, proposing a solution that would be a very substantial advance.

PAS-00-112 [grants.nih.go]: Technologies for Closing DNA Sequence Gaps and Improving Methods for Obtaining the Sequence of Difficult-to-Sequence Regions
The list of clones below are provided by sequencing centers for use by applicants to PAS-00-112. These are clones that were either difficult to finish or that contain gaps. These lists are provided for your use, but you are not required to use these clones.

• Clone List 1
• Clone List 2
• Clone List 3

NHGRI PA-97-044: Technologies for Genomic Mapping, Sequencing, and Analysis
Solicits investigator-initiated proposals to develop new technologies.

NHGRI PA-97-045: Pilot Projects or Feasibility Studies for Genomic Mapping, Sequencing and Analysis (R21)
Supports technology development research for high-risk, high-payoff projects for which little or no preliminary data may be available. Support is for a maximum of two years at $100,000 direct costs per year.

Expired Grant Solicitations

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Program Staff

Program Directors
Jane Peterson, Ph.D.
E-mail: jp22d@nih.gov

Adam Felsenfeld, Ph.D.
E-mail: af59t@nih.gov

Mark Guyer, Ph.D.
E-mail: mg25m@nih.gov

Program Analysts

Kris Wetterstrand, M.S.
E-mail: wettersk@mail.nih.gov

Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305

Phone:(301) 496-7531
Fax:(301) 480-2770

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Last Updated: October 2004