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Alternative names Return to top
Acquired qualitative platelet disorders; Acquired disorders of platelet functionDefinition Return to top
Acquired platelet function defects are non-hereditary diseases or associated conditions that cause the platelets (the blood cells essential for coagulation) to not function properly.Causes, incidence, and risk factors Return to top
Platelets are blood cells that are essential for blood clotting. Platelet disorders can include inappropriate number of platelets (too many or too few), or normal number but inappropriate functioning of the platelets. Any platelet disorder affects blood clotting.
Disorders of platelet function can be caused by congenital diseases or acquired conditions. Acquired platelet function disorders are disorders of inappropriate platelet function, and that develop as a result of another disease or condition (acquired). In many cases, the platelet count may be normal or even elevated, but evidence of a bleeding disorder will be present. Myeloproliferative disorders such as primary thrombocytopenia, polycythemia vera, chronic myelogenous leukemia, and myelofibrosis can produce abnormalities in platelet function.
Other causes include renal failure, multiple myeloma, and medications such as aspirin and other anti-inflammatory medications, penicillins, phenothiazines, and prednisone (prolonged use).
Symptoms Return to top
Signs and tests Return to top
Treatment Return to top
Treatment is directed at the cause of the abnormality. Dialysis reduces the bleeding tendency if the cause is renal failure. Platelet transfusions or plateletpheresis (removal of platelets from the blood and replacement with donated platelets) may be indicated in myeloproliferative disorders. Medication-induced platelet abnormalities require discontinuation of the medication.Expectations (prognosis) Return to top
Treatment of the cause of the abnormality usually corrects the defect.Complications Return to top
Calling your health care provider Return to top
Prevention Return to top
Care in the use of medications can reduce the risk of drug-related acquired platelet function defects. Treatment of other disorders may also reduce risk. Some cases are not preventable. Update Date: 8/18/2003 Updated by: Corey Cutler, M.D., M.P.H., F.R.C.P.C, Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor in Medicine, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |