Skip navigation | ||
|
||
Medical Encyclopedia |
|
Other encyclopedia topics: | A-Ag Ah-Ap Aq-Az B-Bk Bl-Bz C-Cg Ch-Co Cp-Cz D-Di Dj-Dz E-Ep Eq-Ez F G H-Hf Hg-Hz I-In Io-Iz J K L-Ln Lo-Lz M-Mf Mg-Mz N O P-Pl Pm-Pz Q R S-Sh Si-Sp Sq-Sz T-Tn To-Tz U V W X Y Z 0-9 |
Contents of this page: | |
|
|
Alternative names Return to top
Rheumatoid spondylitis; Spondylitis; SpondylarthropathyDefinition Return to top
Spondylitis involves inflammation of one or more vertebrae. Ankylosing spondylitis is a chronic inflammatory disease that affects the joints between the vertebrae of the spine, and the joints between the spine and the pelvis. It eventually causes the affected vertebrae to fuse or grow together. (See arthritis).Causes, incidence, and risk factors Return to top
The cause of ankylosing spondilitis is unknown, but genetic factors seem to play a role. The disease starts with intermittent hip and/or lower-back pain that is worse at night, in the morning, or after inactivity.
Back pain begins in the sacroiliac joint (between the pelvis and the spine) and may progress to include the lumbosacral spine and the thoracic spine (chest portion of the spine).
Pain may be eased by assuming a bent posture. Limited expansion of the chest occurs because of the involvement of the joints between the ribs. The symptoms may worsen, go into remission, or stop at any stage.
With progressive disease, deterioration of bone and cartilage can lead to fusion in the spine or peripheral joints, affecting mobility. It can be extremely painful and crippling. The heart, the lungs, and the eyes may also become affected.
The disease most frequently begins between age 20 and 40, but may begin before age 10. It affects more males than females. Risk factors include a family history of ankylosing spondylitis and male gender. About 0.21% of Americans over age 15 are affected.
Symptoms Return to top
Signs and tests Return to top
A physical examination and characteristic symptoms are indicative of limited spine motion or chest expansion.Treatment Return to top
The goal is to relieve the joint pain and to prevent, delay, or correct deformities.
MEDICATIONS
Nonsteroidal anti-inflammatory medications (NSAIDs) such as aspirin are used to reduce inflammation and pain associated with the condition. They allow patients to exercise, which improves posture and breathing.
DO NOT give aspirin or other NSAIDs to children unless advised to do so by the health care provider!
Corticosteroid therapy or medications to suppress the immune system may be prescribed to control various symptoms. Some health care professionals use cytotoxic drugs (drugs that block cell growth) in people who do not respond well to corticosteroids or who are dependent on high doses of corticosteroids.
Drugs called TNF-inhibitors have been shown to improve the symptoms of ankylosing spondylitis.
SURGERY
Surgery is done if pain or joint damage is severe.
LIFESTYLE CHANGES
Exercises can help improve posture and breathing. Lying flat on the back at night can help maintain normal posture. Use devices to help with activities of daily living.
Expectations (prognosis) Return to top
The course of the disease is unpredictable; remissions and relapses may occur at any stage. Most people are able to function unless the hips are severely involved.Complications Return to top
Calling your health care provider Return to top
Call your health care provider if you have symptoms of ankylosing spondylitis or if you have ankylosing spondylitis and new symptoms develop during treatment.Prevention Return to top
Prevention is unknown. Awareness of risk factors may allow early detection and treatment. Update Date: 8/6/2003 Updated by: Megan E. B. Clowse, M.D., M.P.H., Division of Rheumatology, Johns Hopkins Hospital, Baltimore, MD. Review provided by VeriMed Healthcare Network.
Home | Health Topics | Drug Information | Encyclopedia | Dictionary | News | Directories | Other Resources | |
Copyright | Privacy | Accessibility | Selection Guidelines U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894 National Institutes of Health | Department of Health & Human Services |
Page last updated: 28 October 2004 |