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The Environmental Genome Project (EGP) was initiated
by the National Institute of Environmental Health Sciences (NIEHS)
in 1998.
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The mission of the EGP is to improve understanding of
human genetic susceptibility to environmental exposures.
The EGP supports the mission of NIEHS, which includes
the goal of understanding how individuals differ in their susceptibility
to environmental agents and how these susceptibilities change
over time.
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Major Research Activities of the EGP:
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Comparative
Mouse Genomics Centers Consortium
A Consortium of Academic Research Centers developing mouse models
to determine functional significance of human DNA polymorphism
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Human DNA Polymorphism Discovery and Characterization
Re-sequencing and functional analysis of polymorphic variants in
environmentally responsive genes
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GeneSNPs Database of Human and Mouse Environmental Responsive Genes
An Environmental Genome Project web resource that integrates gene, sequence, and polymorphism data into individually annotated gene models. The human genes included are related to DNA repair, cell cycle control, cell signaling, cell division, homeostasis, and metabolism, and are thought to play a role in susceptibility to environmental exposure.
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Ethical, Legal, and Social Implications
The ELSI program seeks to bring together community groups, environmental health researchers, and behavioral/social scientists to better understand the ethical, legal and social implications of environmental health research.
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Molecular Epidemiology
Collaborative efforts between scientists working in the fields of epidemiology, environmental health sciences, molecular biology, and biostatistics to plan novel and innovative molecular epidemiology studies of environmentally induced diseases. |
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