Instructions
The purpose of the Human Genome Epidemiology
(HuGE) fact sheet is to provide a rapid public health response
to genetic discoveries. Fast facts from HuGENetT will identify
the gene, the variants, and associated diseases and will summarize
what we know and what we don't know about the impact of the
genetic discoveries on disease prevention and health promotion.
The audience is primarily public
health professionals, program developers, policy makers, and
legislators.
The language should be professional
and yet simple enough to be understood by a reader who may not
have a background in genetics. We will be providing a glossary.
However, having to constantly refer to a glossary can be distracting
to the reader. Be brief and simple to keep your reader's attention.
The template is self-explanatory
but you should remember:
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Items 1 and 2 should be accurate
but only one sentence or two. |
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Items 5, 6, and 7 will probably
contain the most important information for the public health
professional. This is our value added section where we make
genetic discoveries relevant to the public health and preventive
medicine. |
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References and web sites should
be current and minimal. Remember, this is not a HuGE review. |
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Please keep the information to
one page; use the front and back. |
Timing is important. It is
our intention to publish the fact sheet within one month of
new genetic discoveries. HuGE fact sheets will be peer-reviewed
for acceptance into HuGENetT. (Note: On occasion, the
peer-review process may extend the timing of publications.)
Questions of a Scientific
Nature should be e-mailed to Bruce Lin, bel9@cdc.gov
or (770) 488-8254.
Questions regarding editing, formatting,
and publication should be mailed to HuGE, HuGE@cdc.gov
or (770) 488-8159.
Formatting, editing, layout,
and clearance will be completed by the communications coordinator
in the CDC's Office of Genomics and Disease Prevention.
Be sure to include your name, telephone number,
e-mail address, and the date of completion.
Mail the completed template to HuGE@cdc.gov
The Office of Genomics and Disease Prevention thanks you for
your participation in our HuGE fact sheet project.
Fast Facts from HuGENetT Template
Author(s) name |
E-mail: |
Telephone: |
Date submitted: |
Revised: |
1. Title
Identify the title of the fact sheet, e.g., ApoE and Alzheimer's
Disease.
2. Gene
Identify the gene being reviewed and provide a brief review
of its chromosome location, the gene product, and its function,
if known. (ONE SENTENCE)
3. Prevalence of Gene Variants
List known allelic variants and summarize current information
on the prevalence of these variants in different populations
and ethnic groups. Describe the populations from which these
data are derived and evaluate the quality and representativeness
of these data (in a FEW SENTENCES, please).
4. Disease Burden
Identify the disease(s) associated with this gene. Summarize
the burden of disease in terms of relative risk, absolute risk,
and attributable fraction in different populations. Comment
on the quality and methodology of studies (briefly).
5. Interactions
Discuss whether the gene variants interact with any of the disease's
known risk factors, including other genes and environmental
factors. Summarize the magnitude of such interactions. Comment
on the quality and methodology of studies (briefly).
6. Laboratory Tests
Summarize the sensitivity, specificity, and predictive values
of biochemical and molecular tests available for this gene in
different populations (briefly).
7. Population testing
Summarize current status of testing for this gene, including
policy statements, recommendations, and legislation. Summarize
data on the magnitude, determinants, and impact of testing on
public health morbidity and mortality (briefly).
8. References
Include relevant Medline citations (3-5 please).
9. Internet sites
Include relevant links to various genetics databases, online
resources, educational materials, policy statements, and support
groups (limit to 3-4).
Fill
out Fact Sheet form online, or e-mail completed form to
HuGE@cdc.gov. |