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"A Framework for a Computational Toxicology Research Program" was crafted by a Technical Writing Team with representatives from all of ORD's Laboratories and Centers. The document describes a framework for the development of a program within ORD to utilize approaches derived from modern computational methods, molecular biology, and systems biology to address the questions of when and how to test specific chemicals for hazard identification and to improve quantitative dose-response assessment.
The overall goal of ORD's proposed research program on Computational Toxicology is to:
- use emerging technologies to improve quantitative risk assessment and
- reduce uncertainties in this source-to-adverse outcome continuum.
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The three strategic objectives of the Computational Toxicology Program described in the document are to develop:
- improved linkages across the source-to-outcome continuum,
- approaches for prioritizing chemicals for subsequent screening and testing, and
- better methods and predictive models for quantitative risk assessment.
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The research program at ORD currently uses many computational and biological approaches associated with the general area of computational toxicology, and examples of such work are described in the document. It is also the case that other research agencies such as the National Institute of Environmental Health Sciences and the Department of Energy have capabilities for research on computational toxicology. ORD has initiated discussions with these agencies in order to facilitate the development of a national approach to the use of computational procedures in toxicology.
"A Framework for a Research Program on Computational Toxicology in ORD" is intended to identify the research needs and unique capabilities of ORD laboratories so as to provide the basis for a more focused and integrated research program in the future.
A consultation with the Science Advisory Board (SAB) of the EPA concerning this document occurred on September 8, 2003; and a workshop involving ORD-EPA scientists and non-EPA researchers was held on September 29 and 30, 2003. Comments received from the SAB and at the workshop were used to revise the document. ORD will use this framework to help develop an implementation plan to guide research on computational toxicology over the next 5-10 years.
Comments or questions concerning the framework can be forwarded to Dr. Robert Kavlock, Director, Reproductive Toxicology Division, US EPA, National Health Effects and Environmental Research Laboratory, Research Triangle Park, NC 27711(919-541-2326).
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