NSF Award Abstract - #0210580| NSF Award Abstract - #0210580 |
AWSFL008-DS3 |
| NSF Org | EEC |
| Latest Amendment Date | April 2, 2004 |
| Award Number | 0210580 |
| Award Instrument | Continuing grant |
| Program Manager |
Tapan Mukherjee EEC DIV OF ENGINEERING EDUCATION AND CENTERS ENG DIRECTORATE FOR ENGINEERING |
| Start Date | September 15, 2002 |
| Expires | August 31, 2006 (Estimated) |
| Expected Total Amount | $1600000 (Estimated) |
| Investigator |
Charles R. Martin crmartin@chem.ufl.edu (Principal Investigator current) Donn Dennis (Co-Principal Investigator current) Jon D. Stewart (Co-Principal Investigator current) Rajiv K. Singh (Co-Principal Investigator current) Richard Rogers (Co-Principal Investigator current) |
| Sponsor |
University of Florida 219 Grinter Hall Gainesville, FL 32611 352/392-1582 |
| NSF Program | 1480 ENGINEERING RESEARCH CENTERS |
| Field Application | |
| Program Reference Code | 0000,1589,1674,7202,9161,AMPP,OTHR, |
This four-year Nanoscale Interdisciplinary Research Team (NIRT) project at the University of Florida with ProfessorCharles R. Martin as principal investigator, conducts a broad-based and systematic investigation of the development of smart nanotubes that are bioengineered and tailor-designed so as to accomplish specific biomedical/biochemical functions. Silica asn polymeric nanotubes will be extensively used in this research effort. Functionalized biodegradable and biocompatible poly( (lactide) nanotubes will be prepared. The objective of the research program include: (1) to show that the chemical microenvironment within biochemically-functionalized nanotubes can be fine-tuned so as promote specific desired biochemical processes; (2) to show that such nanotubes can be capped via self-assembly chemistry with nanoparticle caps; (3) to demonstrate that these nanoparticle caps can be attached via chemical bond that dissociate when a specific intercellular chemical signal is detected; (4) to show that such nanotubes can be tagged on their outer surfaces with antibodies that recognize specific cell types; and (5) to prove that all of these concepts can be used in concert to design new nanotube-based DNA transfection vechicles that deliver genetic material to specific desired cell types.
