Foreword

Genomics and Population Health, 2003: Year at a Glance

Genomics Lingo…..What Do the Terms Mean?

List of Authors

I. Population Health Research

• Chapter 1
  National Health and Nutrition Examination Survey (NHANES) III DNA Bank:
  Gene Variants Important to Public Health
  NHANES III DNA Bank • Collaborative CDC-Wide Proposal • Selecting Genetic Variants Important to Public Health • Potential Value for Public Health • Two Other CDC Projects Using NHANES III DNA Samples

• Chapter 2
  Genomics and Acute Public Health Investigations
  What is an Acute Public Health Investigation (APHI)? • Incorporating Human Genomics into APHIs • APHI Working Group

II. Building the Evidence Base

• Chapter 3
  Asthma Genomics: Implications for Public Health
  What Causes Asthma? • Public Health Implications of Asthma Genomics Research
  • Pharmacogenomics and Predictive Testing • Public Health Actions—Asthma Genomics Research

• Chapter 4
  Public Health Assessment of BRCA1 and BRCA2 Testing for Breast and Ovarian Cancer
  Breast and Ovarian Cancer: An Important Public Health Problem • Genetic Tests for Breast and Ovarian Cancer Susceptibility • A Public Health Perspective • The Role of Family History in BRCA1 and BRCA2 Testing • The Role of Genetic Counseling in BRCA1 and BRCA2 Testing • Surveillance and Risk-Reducing Strategies for Breast and Ovarian Cancer
  • Evaluation of BRCA1 and BRCA2 Testing in Practice • Effectiveness of BRCA1 and BRCA2 Testing for Prevention

• Chapter 5
  Newborn Screening for MCAD Deficiency
  What is MCADD? • Why Test Newborns for MCADD? • Tandem Mass Spectrometry Screening Test • Adding MCADD Screening to Existing Newborn Screening Programs • Is Universal Screening for MCADD Justified? • Cost-Effectiveness of Newborn MCADD Screening
  • Challenges for Implementing MCADD Screening

• Chapter 6
  The Family History Public Health Initiative
  Family History is Valuable for Prevention • Disease Risk Due to Gene-Environment Interactions • Role of Genetic Testing • Family History and the Family Tree • The CDC Family History Initiative • Selecting Diseases to Include in a Family History Tool • Prototype Family History Tool • Data Collection • Classification • Intervention • Evaluation Studies

• Chapter 7
  Genetic Testing and the Prevention of Coronary Heart Disease: A Case Study
  Will a Genomic Profile Help Prevent Coronary Heart Disease (CHD)? • Is Genomic Profiling for CHD Ready for Prime Time? • Medical Family History as Genomic Profiling • Family History is Still the Best Genomic Tool • Guidelines for CHD Prevention

• Chapter 8
  Genomics and Public Health: Ethical, Legal, and Social Issues
  Ethical, Legal, and Social Issues (ELSI) • Public Health Ethical Legal, and Social Issues (PHELSI) • Is PHELSI Different from ELSI? • Public Health Ethics • Ethical Issues in Public Health Genomics • Legal Issues in Public Health Genomics • Social Issues in Public Health Genomics • Engagement and Education to Address PHELSI • A Genetic Agenda for Public Health

III. Genomics in Practice

• Chapter 9
  Carrier Testing for Cystic Fibrosis: Transition from Research to Clinical Practice
  About Cystic Fibrosis • CFTR: The CF Gene • Cystic Fibrosis Carrier Testing • History of CF Testing in the United States • CF Testing in the United States: Transition from Research to Clinical Practice • Evaluation of Prenatal CF Screening • 2003: Learning from Implementation and Practice • Public Health Importance of Lessons Learned

• Chapter 10
  Ensuring the Quality of Genetic Testing in the United States
  Why is the Quality of Genetic Testing Important to Public Health? • Genetic Testing Issues • Who Considers These Issues in the United States? • What Oversight Currently Exists for Genetic Testing? • “Home Brew” Genetic Tests and the FDA • How Do States Regulate Genetic Testing? • What Private Sector Organizations Are Concerned with Genetic Testing? • What is Needed to Ensure the Safety of Genetic Testing? • How is CDC Addressing These Needs?

• Chapter 11
  Hemochromatosis: Information and Resources for Health Care Providers
  What is Hemochromatosis? • Why is Hemochromatosis a Public Health Problem? • Is Population Screening Recommended for Hemochromatosis? • CDC’S Online Training on Hemochromatosis for Health Care Providers

• Chapter 12
  Genomics Training for Public Health Practice: The Michigan Experience
  Why Does the Public Health Workforce Need Genomics Training? • What Has Been Done to Develop Genomics Training? • Simple Training Strategies and Available Courses • Strategy 1: Building a Foundation—Know Your Audience • Strategy 2: Raising Awareness and Stimulating Interest • Strategy 3: Increasing Knowledge • Strategy 4: Strengthening Skills
  • Strategy 5: Using Evaluation to Improve Training • Lessons Learned

• Chapter 13
  Genomics Tools for Public Health
  What are Genomic Tools? • Genomic Tools in Practice and the Genomics Toolkit • Genomic Tools We Need, But Don’t Currently Have • How Will New Tools Be Developed? • Thinking Genomically—the Vision for the Future

• Chapter 14
  State Capacity Grants for Integrating Genomics into Chronic Disease Prevention Programs
  Michigan, Minnesota, Oregon and Utah Genomics and Chronic Disease Prevention Programs • Michigan • Minnesota • Oregon • Utah • Next Steps

• Chapter 15
  Internet Resources for Genomics and Disease Prevention
  CDC Office of Genomics and Disease Prevention (OGDP) • Human Genome Project
  • Genomic Research • Genetic Testing • Family History • Genes and Diseases • Cancer
  • Birth Defects • Newborn Screening • Public Health Ethical, Legal, and Social Issues (PHELSI) • Policy • Public Health Resources • Educational Resources