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	GISP Homepage
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	Annual GISP Reports
	GISP Protocol
	GISP Coding Guide
	GISP Forms Form 1 (clinic) Form 2 (lab) Form 3 (lab)
	QRNG Health Alerts and Treatment Guidelines
	Interpretive Criteria for Susceptibility Testing
	Recommendations for Local Susceptibility Testing
	NonGISP Susceptibility Data
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Homepage

Increases in fluoroquinolone-resistant Neisseria gonorrhoeae among men who have sex with men, United States, 2003, and change in treatment recommendations - MMWR April 30, 2004

Oral Alternatives to Cefixime for the Treatment of Uncomplicated Neisseria Gonorrhoeae Urogenital Infections - Updated April 30, 2004

Areas around the world with increased QRNG prevalence

For additional information, please see:

	Recommendations for Local Susceptibility Testing
	QRNG Health Alerts and Treatment Guidelines

Background

Welcome to the Gonococcal Isolate Surveillance Project (GISP) homepage! GISP was established in 1986 to monitor trends in antimicrobial susceptibilities of strains of N. gonorrhoeae in the United States in order to establish a rational basis for the selection of gonococcal therapies. GISP is a collaborative project between selected sexually transmitted diseases (STD) clinics, five regional laboratories, and the Centers for Disease Control and Prevention (CDC).

Overview of Surveillance System

In GISP, N. gonorrhoeae isolates are collected from the first 25 men with urethral gonorrhea attending STD clinics each month in approximately 28 cities in the United States. At regional laboratories, the susceptibilities of these isolates to penicillin, tetracycline, spectinomycin, ciprofloxacin, ceftriaxone, cefixime, and azithromycin are determined by agar dilution. Minimum inhibitory concentrations (MICs) are measured, and values are interpreted according to criteria recommended by the National Committee for Clinical Laboratory Standards (NCCLS).

For more information, please email: GISP Coordinator (pzw5@cdc.gov)

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GISP	Gonococcal Isolate Surveillance Project