Experimental Vaccine Stops
Shipping Fever in Feeder Calves
An
ARS-developed experimental vaccine should
be very effective in cattle against shipping fever, the leading cause of
illness and death in U.S. feedlots.
The experimental
vaccine was created by deleting a large piece of a specific gene from bacteria
that cause shipping fever. When this gene segment is removed, the bacterium no
longer causes pneumonia in cattle, but does elicit immunity. Veterinarian
Robert E. Briggs and microbiologist Fred M. Tatum at the
National Animal Disease Center in
Ames, Iowa, created the
live vaccine without foreign DNA.
The
Biotechnology Research and Development
Consortium of Peoria, Ill., funded part of the research and applied for
several patents on the vaccine. The vaccine has not yet been approved by the
U.S. Department of Agriculture's (USDA)
Animal and Plant Health Inspection Service (APHIS) for use in the United States.
Bovine respiratory
disease costs cattle producers more than $1 billion annually in losses. It's
also called "shipping fever" because calves develop it about one week after
being shipped to feedlots where they finish growing. Shipping fever results
from an interaction of stress, the animal's immune system, and infectious
pathogens. Bacteria invade the animal's lower respiratory system, causing
pneumonia. The respiratory disease reduces the animal's weight gains, adversely
affects feed efficiency, increases antibiotic costs, and decreases meat and
hide quality, in addition to causing cattle deaths.
In a 1999 study of the top 12
cattle-producing states, the USDA estimated that 97.6 percent of feedlots had
at least one animal with shipping fever.
The new
ARS-developed vaccine could be administered by a variety of routes, including
standard injections or as a novel oral vaccine.
The oral vaccine
protects the animals within three to four days after being added to feed,
instead of the seven-to10-day wait required with injectable vaccines. In a
field trial with the new experimental vaccine, the mortality rate among
vaccinated high-risk calves was 4 percent, compared to 16 percent among
unvaccinated ones. The bacterium Mannheimia haemolytica, the leading
source of shipping fever, was the culprit in all of the deaths of the
unvaccinated animals, but killed none of the vaccinated ones. During the first
28 days on feed, low-risk calves that received the oral vaccine had a 25
percent higher weight gain on average than untreated cattle. Additional field
trials have confirmed the weight-gain advantage during the first 35 days of
feeding.
A major drug firm
has licensed the technology and hopes to market a multivalent injectable
vaccine using the genetically-modified strains of Mannheimia (formerly
Pasteurella) haemolytica and P. multocida.
For more
information, contact:
Robert E. Briggs or
Fred M. Tatum,
Ames, Iowa
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Research Briefs
The first national
genetic database
for dairy cattle fertility will help breeders select for reproductive
performance. Duane
Norman (301) 504-8660
ARS scientists are studying the amounts of
dust produced in
various sections of cattle feedlots and measuring the dust's contents for
harmful properties. Daniel N.
Miller (402) 762-4100
An ARS scientist co-developed an improved method
for supplying
farm-raised catfish with oxygen during a crucial production stage.
Les Torrans (662)
686-5460
Thanks to an ARS researcher, a
compound from a
weed may help catfish farmers battle the ram's horn snail.
Kumudini Meepagala (662)
915-1030
ARS studies show remote sensing matches
grazing animals with
the right forage more quickly and more easily.
Patrick Starks (405)
262-5291
Central and Northern Great Plains cattle could
soon be enjoying three
new wheatgrass cultivars developed by ARS scientists and cooperators.
Ken Vogel (402)
472-4206
Swine at various locations in the country
receive different
levels of nutrients from the same feed mixtures, according to results from
a collaborative study. JT
Yen (402) 762-4206
A new test developed by an ARS scientist tells
trout breeders and researchers which fish are
genetically
inclined to develop more muscle and less fat.
Kenneth E. Overturf (208)
837-9096
ARS researchers are gaining
insight into trout
genetics so they can breed faster-growing, disease-resistant fish.
Caird E. Rexroad III (304)
724-8340, ext. 2129
A new technique developed by an ARS scientist
helps keep Double-crested
cormorants from plundering catfish farm ponds.
Andy Radomski (870)
673-4483, ext. 290
Awards
Janice M. Miller, a veterinarian at the
National Animal Disease Center, was
one of two scientists this year inducted into the ARS Hall of Fame. Miller was
recognized for pioneering research in
understanding, diagnosing and controlling bovine leukemia, transmissible
spongiform encephalopathies and other chronic infectious or zoonotic diseases
of ruminant animals.
Louis Gasbarre, a microbiologist with the Immunology and Disease Resistance
Laboratory in Beltsville, MD, recently received the 2003 Distinguished
Veterinary Parasitologist Award of the American Association of Veterinary
Parasitologists. The award is the highest honor bestowed by the scientific
society. According to their Web site, the award "honors contributions to
veterinary parasitology that are widely recognized internationally as
significant and important to the understanding and control of parasitic
diseases of animals."
Healthy Animals
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