The HPV Voluntary Challenge Chemical List

The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. The U.S. HPV chemicals were identified through information collected under the Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR). Organic chemicals that are manufactured in, or imported into, the United States in amounts equal to or exceeding 10,000 pounds per year are subject to reporting under the TSCA IUR. Reporting is required every four years.

The HPV Challenge Program Chemical List consists of all the HPV chemicals reported during the 1990 IUR reporting year. Inorganic chemicals and polymers, except in special circumstances, were not subject to the IUR reporting requirements, although a number were reported in error. The HPV Challenge Program Chemical List contains about 2,800 chemicals.

The 1990 IUR list was selected as the starting point for this program. As subsequent reporting years identify additional chemicals (including inorganics, once the corresponding reporting requirements have been added under the IUR), they will be posted here for information purposes. EPA expects that, over time, the testing of new HPV chemicals will become routine, and companies may wish to test new HPV chemicals as they appear.

In keeping with that eventual goal, EPA posted the 1994 List of HPV Additions, which contains about 500 organic HPV chemicals which were newly reported as HPV in the 1994 IUR and are thus not part of the HPV Challenge Program at this time. This list is being provided particularly for use by companies who desire to propose categories of chemicals for testing and wish to include chemicals from the 1994 list in their category definitions. In some cases, companies or consortia have sponsored chemicals that are not on either the HPV Challenge Program Chemical List or the 1994 List of HPV Additions. A list of these chemicals, called "Additional Chemicals Sponsored Under the HPV Challenge Program" is also available.

Each list contains the Chemical Abstract Services (CAS) registry number, which is a unique identification number assigned to a chemical; an indicator variable signifying whether the chemical falls outside the scope of the HPV Challenge Program; the chemical name; the chemical sponsorship status; and the sponsor commitment information. The explanations of the various values used in the indicators and status columns can be viewed under the "How to Use the Lists" button. Searches for CAS numbers, chemical names, indicators, chemical sponsorship status, and sponsor commitment status may be conducted using the "Search" function. Lists may be downloaded in either Portable Data Format (PDF) or database format (DBF).

These lists have been annotated periodically since they were first posted on October 9, 1998. Only the most recent description of updates to the lists is shown below. To view a chronology of amendments to the lists, please consult the " Chemical List History" button.

May 28, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of “1.” This chemical may be sponsored, however.

No new indicators of "1" were added.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of “2.” This chemical may be sponsored, however.

An indicator of “2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

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