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Alternative names
Hemolysis - acuteDefinition Return to top
Hemolytic crisis is the rapid destruction of red blood cells (hemolysis) beyond that for which the body can compensate by increasing blood cell production.Considerations Return to top
Rapid destruction of red blood cells (RBCs) can be triggered in a wide variety of conditions, both because of defects within the cell and abnormalities in the blood environment. These conditions are called hemolytic anemias.
Anemia is present because there is always some degree of hemolysis with resulting decreased hematocrit. In some hemolytic anemias, such as glucose-6-phosphate dehydrogenase deficiency (G6PD), exposure to certain chemicals can synchronize the destruction of the RBCs.
Massive RBC destruction causes an acute (and often profound) anemia because the body is unable to compensate by making enough blood cells to replace those destroyed. This can also cause overloading of the kidneys with free hemoglobin. Hemolytic crises in G6PD can be fatal.
Common Causes Return to top
Home Care Return to top
Consult your health care provider.Call your health care provider if Return to top
What to expect at your health care provider's office Return to top
Emergency treatment may be necessary. This may include hospitalization, administration of oxygen, blood transfusions, and other treatments.
When your condition is stable, your medical history will be obtained and a physical examination will be performed.
Medical history questions documenting hemolytic crisis in detail may include the following:
The physical examination may occasionally show enlargement of the spleen (splenomegaly).
Diagnostic tests may include the following:
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Page last updated: 28 October 2004 |