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Division of Laboratory Sciences

National Report on Human Exposure to Environmental Chemicals

Biomonitoring at a Glance

Biomonitoring Program

Background

Biomonitoring is the direct measurement of environmental chemicals, their primary metabolites, or their reaction products (such as DNA-adducts) in people--usually in blood or urine specimens. Currently, human exposure information is limited.  Reliable and accurate exposure data are required for studies that examine the relation between exposure and adverse health effects.  Decision makers need information about which environmental chemicals actually get into people and at what levels to make decisions about public health issues that will benefit the American public.

For more than 25 years, DLS has measured environmental chemicals in people, both for national studies of general population exposure and for studies of specific potentially exposed populations.  The Biomonitoring Program continues to assess exposures ranging from those causing deaths during acute emergencies to exposures that may cause cancer, birth defects, or neurologic or other diseases.  We collaborate with other Centers, Institutes, and Offices (CIOs), including the Agency for Toxic Substances and Disease Registry (ATSDR), the National Center for Health Statistics (NCHS), the National Institute for Occupational Safety and Health (NIOSH). We also collaborate with many federal agencies, including the U.S. Environmental Agency (EPA), the Food and Drug Administration (FDA), the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI) of the National Institutes of Health (NIH); state and local health departments; the World Health Organization (WHO); and academic institutions.

Goal of the Biomonitoring Program

The goal of the Biomonitoring Program is to help prevent environmental disease by doing the following:  
 

  • Determine which environmental chemicals actually get into people.

  • Measure how much exposure each person has.
    Assess exposure for health studies of exposed populations.

  • Determine which population groups, such as minorities, people with low incomes, children, or the elderly, are at high risk for exposure and adverse health effects.

  • Assess the effectiveness of public health interventions to reduce exposures.

  • Monitor trends in exposure levels over time.

Biomonitoring requires the use of analytical methods that are  sensitive and specific (i.e., they are able to measure chemicals at very low levels, such as  parts-per-trillion or parts-per-quadrillion, in the presence of many other chemicals.  DLS has developed methods to measure more than 200 substances in human blood, serum, and urine.  Typically, we measure these low levels in a small amount of blood or urine, from 50 microliters (µL) to 5 milliliters (mL). 

What chemicals are measured? 

Some of the chemicals measured are (list of classes with examples):

  • Polychlorinated biphenyls (PCBs)

  • Dioxins

  • Furans 

  • Persistent organic pollutants (POPs)
    DDT, and its metabolite DDE

  • Non-persistent organic pesticides and their metabolites

  • Polyaromatic hydrocarbon metabolites

  • Phthalate metabolites

  • Metals

  • Volatile Organic Compounds

  • Phytoestrogens

Other Links

National Health and Nutrition Examination Survey (NHANES)

Air Force Health Study 

Tobacco

Lead

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This page last reviewed August 05, 2004

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