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Office of Genomics and Disease Prevention
       
 Thursday, October 7, 2004 Volume 13   Number 15    
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public  
This weekly update provides information about the impact of human genetic research on disease prevention and public health.
 

Spotlight
     
 

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Genomics for Public Health Practitioners is a 45-minute presentation that serves as an introduction to genomics and public health as well as the larger education resource called Six Weeks to Genomics Awareness.

Based on comments and feedback from our readers, we have decided to change some features of the Genomics and Health Weekly Update. Similar to the original format, you can now link directly to the expanded version of the Update. Special articles will continue to be highlighted each week and you will have the ability to print the condensed one-page menu, if you are interested.

We appreciate your feedback and your commitment to the advancement of Genomics.

Announcements

CDC sponsored material The Case for a Global Human Genome Epidemiology Initiative
Article by Muin J. Khoury, Sep (2004)

CDC sponsored material Family history of heart disease and cardiovascular disease risk-reducing behaviors
McCusker ME et al. Genet Med 2004;6:153-158

 
Genomics In The News

Featured item
“Surgeon general's office promoting family medical history”
(October 3) AP via Daily Comet reports, “Knowing which diseases run in your family can save lives, so the government is working to make such family histories easy for anyone to put together, U.S. Surgeon General Richard H. Carmona says.”

“Agilent Technologies Donates Microarrays to Vanderbilt University for Courses in Genomic Technologies, Bioinformatics”
(October 6) Business Wire via Yahoo! reports, “Agilent Technologies Inc. (...) and Vanderbilt University Medical Center (VUMC) today announced that Agilent has donated cDNA microarray kits valued at $66,000 to the medical center.”

“Orkney to help battle for health”
(October 6) BBC News reports, “A new two-year study is being launched on Orkney to tackle Scotland's top three life-threatening diseases - heart disease, stroke and diabetes.”

“Science mourns DNA pioneer Wilkins”
(October 6) BBC News reports, “DNA pioneer Professor Maurice Wilkins has died.”

“Breast density, rapid tumor growth reduce mammogram sensitivity”
(October 5) Reuters Health via OncoLink reports, “Breast tissue density of women in their 40s, as well as a propensity to more rapidly growing tumors, contribute to their increased chance of having a cancer detected after a negative screening mammogram, new study findings suggest.”

“Guidelines clear way for gene-screen babies”
(October 5) The New Zealand Herald reports, “New Zealand parents will soon be able to have babies free of serious genetic disorders and babies whose tissue can be used to help ill siblings.”

“Sudden infant death syndrome”
(October 5) USNews.com reports, “Faulty genes may be responsible for some SIDS deaths.”

“NIH Funds First National SNP Genotyping Center at Broad Institute”
(October 5) NIH/NCRR report, “The National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), announced today it will fund the first national center for high-throughput genotyping dedicated solely to large-scale SNP (single nucleotide polymorphism) analysis at the Eli and Edythe L. Broad Institute of MIT and Harvard University in Cambridge, Mass.”

“ParAllele Bioscience Enters Collaboration To Study Genetics Of Heart Disease”
(October 5) PRNewswire via BioSpace reports, “ParAllele BioScience announced today that it has entered into collaboration with Novartis Pharma AG to discover genetic variations associated with coronary artery disease.”

“Sibling History Predicts Early Heart Disease Better Than Parental History”
(October 4) Johns Hopkins Medicine reports, “Researchers at Johns Hopkins have found that sibling history -- whether or not a brother or sister had early heart disease -- is a better predictor of a person's likelihood of developing coronary heart disease than parental history or traditional risk factor scoring.”

“Discovery Health Channel Profiles Several Families Coping With Breast Cancer in Breast Cancer Legacy”
(October 4) PRNewswire reports, “The One-Hour Special Hosted and Narrated by Meredith Baxter Airs Thursday, October 28th, Commemorating October's Breast Cancer Awareness Month.”

“Scientists Begin Validation Study of Test to Detect Recurrence of Bladder Cancer”
(October 4) National Cancer Institute reports, “A three-year study to validate a test to detect the recurrence of bladder cancer has been initiated by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), at 12 centers* across the United States and Canada.”

“Mayo Clinic awarded major NIH contract for smallpox genomics research”
(October 4) Mayo Clinic via EurekAlert reports, “Vaccine researchers at Mayo Clinic have been awarded a $10 million federal contract to study genetic susceptibility to smallpox and genomic-based risks to the smallpox vaccine.”

“Genome Model Applied to Software”
(October 4) Wired News reports, “What does uncovering the secret language of DNA have in common with reverse-engineering Microsoft software?”

“Richard Axel and Linda Buck Awarded 2004 Nobel Prize in Physiology or Medicine”
(October 4) HHMI reports, “The Nobel Assembly at the Karolinska Institute announced this morning that the 2004 Nobel Prize in Physiology or Medicine was awarded to Richard Axel, an HHMI investigator at Columbia University College of Physicians and Surgeons, and Linda Buck, an HHMI investigator at the Fred Hutchinson Cancer Research Center.”

“Obesity the disease of the millennium”
(October 4) Medical News Today reports, “Once considered an aesthetic rather than a medical problem, obesity is now officially recognised as a major public health problem.”

“Guidelines for genetic testing of human embryos”
(October 4) Ministry of Health via Scoop reports, “The public is being asked for its views on proposed guidelines covering the testing of human embryos for serious inherited genetic conditions.”

“Study: Food Restrictions on Kids Backfire”
(October 4) HealthDay News reports, “If your child is at high risk for being overweight or obese, restricting food probably isn't the best way to try to keep the youngster at a healthy weight.”

“Advancements in Genomics and Proteomics Broaden the Role of Biomarkers in Healthcare”
(October 4) Business Wire reports, “Having successfully deciphered the human genome, researchers are now shifting focus to solve the riddle of human proteome - that is proteins - the ultimate product of gene expression.”

“EXACT Sciences Presents Research on New DNA Stabilization Techniques, Scanning Methods and Genetic Markers”
(October 3) Investors Business Daily reports, “EXACT Sciences Corporation (EXAS) announced today that its Chief Technology Officer, Anthony P. Shuber, will present information on the Company's latest applied research efforts on Sunday, October 3, 2004 at 8:00 am (EDT).”

“Brain-boosting Drug Promising for Down Syndrome”
(October 1) Betterhumans reports, “A drug approved for treating people with Alzheimer's also appears to boost language ability in children with Down syndrome.”

“Artificial Neural Networks Can Predict Clinical Outcomes of Neuroblastoma Patients”
(October 1) NIH/NCI report, “Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), have used artificial neural networks (ANNs) and DNA microarrays to successfully predict the clinical outcome of patients diagnosed with neuroblastoma (NB).”

“Researchers Pinpoint Cause of a Severe Cardiac Arrhythmia”
(October 1) HHMI reports, “Howard Hughes Medical Institute researchers have pinpointed the genetic cause of a devastating but rare childhood disorder, called Timothy syndrome, which underlies a form of severe cardiac arrhythmia.”

“Cancer Gene Map Spans 22 Types of Tumors”
(October 1) Genome News Network reports, “A team of computer scientists and a biologist have created a new type of cancer gene map that brings together a diverse collection of genomic information and identifies sets of genes that are active in a variety of tumors.”

“Adult ADHD: An Overlooked Problem”
(October 1) HealthDay News reports, “Attention-deficit/hyperactivity disorder (ADHD) is one of the most publicized, and controversial, childhood disorders in the United States.”

“UEGW 2004: Chromosome Translocation Found That Might Help Identify at Risk Patients With Gastric Lymphoma”
(October 1) Doctor’s Guide reports, “Translocation of the t(11;18) chromosome in patients with gastric lymphoma of the mucosa-associated lymphoid tissue type (MALT) can be used as a marker of resistance to alkylating agents and to identify patients who require an aggressive treatment protocol, according to a study presented here September 28th at the 12th United European Gastroenterology Week.”

“DNA sequence controls expression of gene involved in cancer”
(October 1) American Society for Biochemistry and Molecular Biology via EurekAlert reports, “Scientists have discovered a DNA sequence that causes the destabilization, and hence decay, of the protooncogene bcl-2 (B-cell lymphoma/leukemia-2).”

“Penn receives grant for initiative to help understand genes' effects on medications”
(October 1) University of Pennsylvania Medical Center via EurekAlert reports, “The University of Pennsylvania School of Medicine has been awarded a major grant from the National Institutes of Health (NIH) to bring together researchers from different disciplines to study gene-drug interactions.”

“NHGRI Awards Perlegen $6 Million to Participate in HapMap Project”
(September 30) GenomeWeb News reports, “Perlegen Sciences has won a $6 million grant from the National Human Genome Research Institute to support the International HapMap Project, the company said today.”

“Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes, Pitt study finds”
(September 30) University of Pittsburgh Medical Center via EurekAlert reports, “The amount of smoke in just one or two puffs of a cigarette can cause breaks in DNA and defects to a cell's chromosomes, leading to irreversible changes in genetic information being passed to a newly divided cell, according to University of Pittsburgh researchers.”

“NIH Awards $18.2 Million to The Burnham Institute to Develop Center on Proteolytic Pathways”
(September 30) The Burnham Institute reports, “The National Institutes of Health (NIH) has selected The Burnham Institute to develop a national resource for medical researchers to be known as the ‘Center on Proteolytic Pathways’.”

“Fourth Gene Found for Distal Muscular Dystrophy”
(September 30) Muscular Dystrophy News reports, “MDA grantees Peter Hedera, a neurologist at Vanderbilt University in Nashville, Tenn., and Nigel Laing, a molecular biologist at the University of Western Australia in Nedlands, were part of a team that identified a fourth gene that, when flawed, leads to distal muscular dystrophy (DD).”

 
Genomics in Scientific Literature

Featured item
Ethical issues in identifying and recruiting participants for familial genetic research
Beskow LM, et al.
Am J Med Genet 2004 Sep

Cardio: a web-based knowledge resource of genes and proteins related to cardiovascular disease
Zhang Q, et al.
Int J Cardiol 2004 Nov;97(2):245-9

Association of prostate cancer family history with histopathological and clinical characteristics of prostate tumors
Spangler E, et al.
Int J Cancer 2004 Sep

Evaluation of the interactions of common genetic mutations in stroke
Szolnoki Z
Methods Mol Med 2004;104:241-50

Practicalities of genetic studies in human stroke
Hassan A & Markus HS
Methods Mol Med 2004;104:223-40

Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?
Mackness M & Mackness B
Free Radic Biol Med 2004 Nov;37(9):1317-23

Newborn screening for medium chain acyl-CoA dehydrogenase deficiency (MCADD) in the UK
Goddard P
J Fam Health Care 2004;14(4):90-2

Study results: employer-based coverage of genetic counseling services
Gibons A
Benefits Q 2004;20(3):48-68

Genetic practice, education, and research: an overview for advanced practice nurses
Beery TA & Hern MJ
Clin Nurse Spec 2004 May-2004 Jun;18(3):126-32; quiz 133-4

FACE facts: why human genetics will always provoke bioethics
Juengst ET
J Law Med Ethics 2004 Summer;32(2):267-75 , 191

Estimation of the familial relative risk of cancer by site from a French population based family study on colorectal cancer (CCREF study)
Andrieu N, et al.
Gut 2004 Sep;53(9):1322-8

 
HuGE Published Literature

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 6, 2004, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 
Upcoming Events

Featured item
new this weekNovember 13, 2004
2004 Scottsdale Healthcare Cancer Genetics Conference
Scottsdale, Arizona
  October 6-10, 2004
Molecular Genetics of Aging
Cold Spring Harbor, New York
   
 

October 9-13, 2004
XIIth World Congress of Psychiatric Genetics 2004
Dublin, Ireland

   
  October 10-15, 2004
3rd International Conference on Innate Immunity
Crete, Greece
   
 

October 14-15, 2004
Implications of Genomics for Health Behavior and Health Education Symposium
Ann Arbor, Michigan

   
new this week November 5-7, 2004
The First International Symposium on Translational Clinical Research for Inherited and Orphan Retinal Diseases
Washington, DC
   
new this week November 8-9, 2004
International Conference on Tumor Progression & Therapeutic Resistance
Philadelphia, Pennsylvania
   
new this week January 17-18, 2005
First International Imaging Genetics Conference
UC Irvine , California
   
new this week February 5-9, 2005
Signal Transduction in Cancer
Miami , Florida
   
new this week July 17-21, 2005
BioScience2005 – from genes to systems
SECC, Glasgow , UK
 
Let's Go Surfing

Featured item
Public Health Genetics Unit, UK, Newsletter, Number 75, October 2004
A newsletter that features news and views about genetics and genetics research from a public health perspective.

NIH Roadmap – Accelerating Medical Discovery to Improve Health
“Initiatives under the NIH Roadmap will help enable the agency to sustain its historic record of making cutting-edge contributions that are central to extending the quality of healthy life for people in this country and around the world.”

Breast Cancer Legacy from the Discovery Health Channel

 

 

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Last Updated October 08, 2004