Division of Kidney, Urologic, and Hematologic Diseases (KUH) Basic Science Projects, Research Centers, Trans NIH Projects

• Basic Science Projects
• Research Centers
• Trans-NIH Projects

Basic Science Projects

Basic Research in Interstitial Cystitis: In November 2002, the NIDDK invited applications for basic cellular, molecular, and genetic research and translational studies focused on understanding the causes and pathogenesis of interstitial cystitis (IC). One aim of this RFA is to attract new and established investigators from related research areas to apply their knowledge to the study of IC.

Non-invasive Measurement of Iron by Magnetic Resonance Imaging: MRI potentially provides a useful and widely available technique for examining the three-dimensional distribution of excess iron in the body, but further research is needed to develop a way to make measurements quantitative.

Hematopoietic Cell Lineage Genome Anatomy Projects (HCLGAP): HCLGAP was established for the purpose of identifying gene expression profiles of hematopoietic stem cells (HSCs) and other cells in the hematopoietic cell lineage in health and disease. The goals are to develop the necessary biological procedures and reagents for characterization of cells of the hematopoietic cell lineage (HCL) and to characterize gene expression patterns in these cells using advanced technologies and bioinformatics techniques.

Research Centers

Centers of Excellence in Molecular Hematology (RFA DK-98-015): The Centers of Excellence are part of an integrated program of hematologic diseases-related research support provided by the NIDDK. They provide a focus for increasing collaboration and improving the cost-effectiveness of supported research among groups of successful investigators at institutions with an established, comprehensive hematologic diseases research base. Current Hematology Centers

George M. O.Brien Urology Research Centers: Established to improve efficiency in research and collaboration among investigators, these centers aim to attract new scientific expertise, encourage multidisciplinary research, encourage translational research, explore new basic science areas that may have clinical trial applications, and generate developmental research/pilot and feasibility studies that will lead to new and innovative approaches to the study of urological diseases. Current Urology Centers

George M. O'Brien Kidney Research Centers: The emphases for this program are to attract new scientific expertise into the study of the basic mechanisms of kidney diseases and disorders; encourage multidisciplinary research focused on the causes of these diseases; explore new basic areas that may have clinical research application; and generate developmental research (DR)/pilot and feasibility (P&F) studies of two years duration. Current Kidney Centers

Centers of Excellence in Pediatric Nephrology: The purpose of this research center is to attract a partnership of interdisciplinary research among investigators with scientific expertise who will use complementary and integrated approaches into the study of kidney diseases endemic to the pediatric population. Extensive collaboration will be required among investigators in the clinical and basic sciences. Current Pediatric Centers

Interdisciplinary Centers for Polycystic Kidney Disease Research: The centers are a partnership of scientific investigators from various disciplines who use complementary and integrated approaches for PKD research. The centers will genetic mechanisms, biology of polycystin function, physiology, pathogenesis, and progression of PKD. They also explore therapeutic strategies. Current PKD Centers

Trans-NIH Projects

The Trans-NIH Zebrafish Initiative: The zebrafish has a number of valuable features as a model organism for study of vertebrate development, including embryos that are transparent and accessible throughout development. The specific objectives of the zebrafish initiative are generation of a genetic map; development of Expressed Sequence Tags (ESTs) and creation of a physical (radiation hybrid) map of the genome. Link to Zebrafish Website

Stem Cell Genome Anatomy Projects (SCGAP): The aims of this consortium are to collectively develop necessary biological procedures and reagents for characterization of tissue-specific progenitor cells and to characterize gene expression patterns in these cells using advanced technologies and bioinformatic techniques. The consortium comprises seven groups; those specific to kidney and urology are the Urologic Epithelial Stem Cell GAP (i.e., bladder and prostate) and the Kidney Stem Cell GAP.

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