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Genetic
Characterization Wild-type measles viruses have been divided into distinct genetic groups according to the nucleotide sequences of their hemagglutinin (H) and nucleoprotein (N) genes, which are the most variable genes on the viral genome. The nucleotide sequence encoding the carboxy-terminus of the nucleoprotein (the last 450 nucleotides) has up to 12% nucleotide variation between the most dissimilar genotypes. For each genetic grouping or genotype, a reference strain is designated for use in genetic analysis (phylogenetic analysis), usually the earliest known virus isolation of that group. The means of referring to the genotypes has been standardized using alphabetical designations for the main groupings (clades). Within the main groups, numerals are added for closely related, but distinct groups that exist or are encountered as more viruses are sequenced.
Citation list of journal articles on measles genotyping and sequencing National
Center for Biotechnology Information (NCBI) GenBank
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This page last reviewed September 15, 2003 |
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