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Search IRIS

IRIS     
List of IRIS Substances Full IRIS Summary   QuickView   

The Search IRIS page enables users to find IRIS files, identify substances with similar toxicological properties, and conduct other comparative analyses of IRIS data. The CASRN and Keyword Search options enable users to determine whether a substance not included on the List of IRIS Substances is listed under a synonym or addressed in IRIS as part of a broader substance category (e.g., Lead and compounds, PCBs). The Keyword Search can also be used to locate information on general topics either within the IRIS summaries and Toxicological Reviews themselves or throughout the entire IRIS Website, including IRIS guidance documents and other background information.

The Search IRIS page also enables users to find substances with similar toxicological properties. The Critical Effect/Precursor Effect/Tumor Type Search enables the user to find substances that effect similar organs or tissues in similar ways. The Evidence for Human Carcinogenicity Search enables the user to find substances by the weight-of-evidence characterizations used in the 1986, 1996, and 1999 Carcinogen Risk Assessment Guidelines. The Quantitative Toxicity and Related Values Search enables users to identify substances within ranges of cancer and noncancer dose-response values, including RfDs, RfCs, slope factors, and unit risks. The Uncertainty and Modifying Factors Search enables users to analyze sources of uncertainty and variability and the application of uncertainty factors for derivation of RfDs and RfCs across the IRIS database.



Search IRIS by Substance Name or CASRN  back to the top

The Search by Substance or CASRN allows IRIS users to enter any substance name or CASRN and get a list of IRIS Substances that match or are a synonym for that substance name or CASRN.  Search Tips

Enter a Substance Name or CASRN:

Search IRIS by Keyword  back to the top

The Search IRIS by Keyword allows IRIS users to search the entire IRIS Web site by entering any keyword and/or string of keywords.

Searching Full IRIS Summaries/Toxicological Reviews will result in a list of relevant substances, each containing links to available Web pages and documents for that substance. Whereas, searching Entire IRIS Website will result in a list of relevant Web site pages and documents.  Search Tips

Enter Relevant Keyword(s):

Full IRIS Summaries/       Entire IRIS Website
      Toxicological Reviews

Search IRIS by Critical Effect(s), Precursor Effect(s) and/or Tumor Type(s)  back to the top

The Search IRIS by Critical Effect/Precursor Effect/Tumor Type allows IRIS users to search the IRIS database for carcinogenic and/or non carcinogenic health effects. This search is limited to health effects used for quantitative estimates for noncancer toxicity and cancer risk.   Search Tips

For alternative terminology to utilize while searching for critical effects, precursor effects and tumor types, refer to the National Library of Medicine (NLM) Medical Subject Headings (MeSH) Browser. Exit EPA For more information on how to use the MeSH with IRIS, refer to the full IRIS description of MeSH.

Enter a Critical Effect(s), Precursor Effect(s) and/or Tumor Type(s):


Select an area to Search  (check all that apply):

Oral RfDs
Inhalation RfCs
Carcinogenic Risk -- Oral
Carcinogenic Risk -- Inhalation

Search by Evidence for Human Carcinogenicity  back to the top

The Search IRIS by Evidence for Human Carcinogenicity allows IRIS users to search the IRIS database to identify substances by weight-of-evidence classifications established by EPA using the 1986, 1996, and 1999 Guidelines for Carcinogen Risk Assessment. These guidelines reflect the evolution of the science in this area and the corresponding evolution of the Agency's approach to characterizing weight-of-evidence for human carcinogenicity. Users should search all possible categories and descriptors that might apply to their particular needs.  Search Tips

Select 1986 Guideline(s) to Search (check all that apply):
A (Human carcinogen)
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in animals)
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
C (Possible human carcinogen)
D (Not classifiable as to human carcinogenicity)
E (Evidence of non-carcinogenicity for humans)


Select 1996 Guideline(s) to Search (check all that apply):
Known/likely human carcinogen
Carcinogenic potential cannot be determined
Not likely to be carcinogenic to humans


Select 1999 Guideline(s) [PDF, 1,026 KB] to Search (check all that apply):
Carcinogenic to humans
Likely to be carcinogenic to humans
Suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential
Data are inadequate for an assessment of human carcinogenic potential
Not likely to be carcinogenic to humans

Search IRIS by Quantitative Toxicity Values  back to the top

The Search IRIS by Quantitative Toxicity Values allows IRIS users to enter a range of numeric values to search the IRIS database for substance toxicity. Follow the steps below.  Search Tips

1.) Select a Type of Toxicity:
     
2.) Enter a minimum to maximum range of Toxicity Values:
    (use the drop-down menus provided below when entering a range in "scientific notation".
    Ex: 2 x 10 -3 to 3.5 x 104)

                                                              
  x 10              to                 x 10                    

Search IRIS by Uncertainty and Modifying Factors  back to the top

The Search IRIS by Uncertainty and Modifying Factors allows IRIS users to search for the composite uncertainty factor values, uncertainty factors and uncertainty factor values, and modifying factor values used to derive RfDs and RfCs. The search will return the identity of the substances for which the selected factors have a selected value or value range. Follow the steps below to search IRIS uncertainty and modifying factors.   Search Tips

1.) Search Composite Uncertainty Factor Values:
     a.) Select Type(s) of Toxicity Value(s):
       Oral RfDs
       Inhalation RfCs

     b.) Select a range of values:
         to 

2.) Search Uncertainty Factor Values:
     a.) Select Type(s) of Toxicity Value(s):
       Oral RfDs
       Inhalation RfCs

     b.) Select Uncertainty Factor(s):
       Interspecies uncertainty
       Intraspecies variability
       Subchronic to chronic extrapolation
       Use of a LOAEL in absence of a NOAEL
       Database incomplete
       Other uncertainty factors

     c.) Select a range of values:
     (use the drop-down menu provided below to select a range.)
      

3.) Search Modifying Factor Values:
     a.) Select Type(s) of Toxicity Value(s):
       Oral RfDs
       Inhalation RfCs

     b.) Select a range of values:
     (use the drop-down menu provided below to select a range.)
      

 

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