The DNA and Chromosome Aberrations Branch (DCAB) plans and administers a broadly-based extramural program of grants on the cancer-related mechanisms of DNA damage/repair, and related molecular, cytogenetic, and chromosomal effects during induction and progression to malignancy. The scientific scope encompasses a number of disciplines, including: DNA damage detection, repair, and response mechanisms, as well as the molecular basis for spontaneous and heritable defects in DNA repair and chromosome stability.
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No announcements at this time. |
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| Biochemistry, Molecular Biology, Genetics, and Structural Biology of carcinogen |
Biochemistry, molecular biology, genetics, and structural biology of carcinogen (e.g., radiation, chemicals, etc.)-induced and endogenous DNA repair mechanisms (e.g., nucleotide and base excision, recombination, mismatch repair pathways)
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| Cytogenetic and Molecular Structure/Function Analysis |
Cytogenetic and molecular structure/function analysis of induced and spontaneous chromosome aberrations that are associated with genomic instability and cancer induction (e.g., translocations, deletions, fragile sites)
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| Discovery |
Discovery, molecular mapping and characterization of new cancer genes
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| Epigenetic Mechanisms |
Epigenetic mechanisms involved in gene silencing and cancer induction
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| Mechanisms of DNA damage |
Mechanisms of DNA damage-inducible signaling, resulting perturbations to the cell-cycle, and regulation of apoptosis or other mechanisms of programmed cell death.
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