LLNL is a National laboratory organized
to facilitate multidisciplinary sharing of facilities and equipment
among its staff. This environment provides libraries at LLNL and
access to University of California libraries. Resource facilities
at LLNL include laboratories for sample preparation, chemical separations,
physical analysis, and cell culture. These laboratories are equipped
with fume hoods, a Nanopure water system, refrigerators, freezers,
water baths, centrifuges, balances, vacuum dryers, incubators for
cell culture. An AAALAC-certified animal care facility is available.
In addition, the following equipment is used by the Resource:
1. The1 MV accelerator mass spectrometer was (see photo below) developed
partially under the Resource funding. 14C and tritium analyses of
biomedical samples submitted by Resource users are conducted using
this 1 MV system. The AMS spectrometer consists of a cesium sputter
source, low-energy injection beam line, the high voltage collision
cell (accelerator), a high-energy mass spectrometer and a particle
detector for energy measurements (proceeding clockwise from lower
left in the photograph).
Another spectrometer is available to the Resource through CAMS:
a 10-MV FN tandem accelerator capable of terminal voltages up to 10
MV with AMS measurement capabilities developed for 3H, 10Be,
14C, 26Al, 36Cl, 41Ca, 63,
59Ni, 99Tc, 129I and 239Pu.
A 1.7 MV tandem proton accelerator for nuclear microscopy that can
measure the masses
of ?g to pg quantities of materials is also situated at CAMS.
2. Micromass Isoprime isotope ratio mass spectrometer.
3. Exeter 440 CHN Analyzer
4. Pharmacia Biotech Wallac 1410 liquid scintillation counter.
5. Branson Sonifier 450 equipped with a cup-horn.
6. Agilent HPLC,
which includes, fluorescent and diode array detectors, thermostated
column guard, auto sampler, binary pump, degasser,
ALS thermostat, and HP laser jet printer. Another HPLC is used
for radiolabeled
materials and is also linked to an online Inus radioanalytic
beta-detector for on-line analysis of radiolabeled compounds.
7.
A Shimadzu UV/VIS spectrophotometer.
8. Biorad isoelectric focusing,
rotofor, tubegel and elution equipment. Two dimensional gel electrophoresis
equipment,
including a Lauda
water bath for cooling.
One laboratory is dedicated to the conversion of samples to uniform
solids for AMS measurement: filamentous graphite for 14C and titanium
hydride for 3H. This laboratory contains three ovens for sample oxidation
and reductions, two tabletop vacuum pumping systems and an oxygen:acetylene
torch for the sealing of quartz and Pyrex tubes under vacuum.
